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IJE Advance Access published online on May 29, 2009
International Journal of Epidemiology, doi:10.1093/ije/dyp217
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2009; all rights reserved.

Cohort Profile: The EPIC-NL study

Joline W J Beulens1,2,*, Evelyn M Monninkhof1, Monique W M Verschuren2, Yvonne T van der Schouw1, Jet Smit2, Marga C Ocke3, Eugene H J M Jansen4, Susan van Dieren1, Diederick E Grobbee1, Petra H M Peeters1 and Bas H B Bueno-de-Mesquita3

1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
2Center for Prevention and Health Services Research, Bilthoven, The Netherlands.
3Center for Nutrition and Health, Bilthoven, The Netherlands.
4Laboratory for Health Protection Research, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

* Corresponding author. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands. E-mail: J.Beulens@umcutrecht.nl

Accepted 22 April 2009

The first 150 words of the full text of this article appear below.


   How did the study come about?
 
A major scientific challenge for the next few decades is to understand the interaction between genetic susceptibility and environmental factors in the aetiology of chronic diseases. The most promising approach to discover these interactions requires a combined effort of epidemiology and molecular genetics and large sample sizes for sufficient power. Already in the early 90s, the European Prospective Investigation Into Cancer and Nutrition (EPIC) was initiated in 10 European countries to create a large cohort to study the aetiology of chronic diseases.1,2 The Netherlands has contributed two cohort studies to EPIC: the Prospect cohort of 17 357 women of the Julius Center3 in Utrecht, and the Monitoring Project on Risk Factors for Chronic Diseases (MORGEN) cohort of 22 654 men and women of the National Institute for Public Health and the Environment (RIVM) in Bilthoven.4 In the design phase, both cohorts collaborated closely to obtain maximal synergy in the design . . . [Full Text of this Article]


   What does it cover?
 

   Who is in the sample?
 

   What was the baseline response rate?
 

   How often have they been followed?
 

   What is the response rate during follow-up?
 

   What has been measured?
 
General questionnaire and physical examination
FFQ
Blood sampling
Biochemical measurements
Disease occurrence
Follow-up questionnaires

   What has been found?
 

   Main strengths and weaknesses
 

   How can I collaborate?
 

   Funding
 

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