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IJE Advance Access published online on October 19, 2008
International Journal of Epidemiology, doi:10.1093/ije/dyn200
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2008; all rights reserved.

Commentary: Observational studies may conceal a weakly elevated risk under the appearance of consistently reduced risks

Rodolfo Saracci1,* and Neil Pearce2

1IFC-National Research Council, Via Trieste 41, 56100 Pisa, Italy.
2Centre for Public Health Research, Massey University Wellington Campus, Private Box 756, Wellington, New Zealand.

*Corresponding author. IFC-National Research Council, Via Trieste 41, 56100 Pisa, Italy. E-mail: saracci@hotmail.com

Accepted 27 August 2008

The first 10% of the full text of this article appears below.

The paper by Lahkola et al.1 is interesting in two respects. First, the issue of possible health effects, in particular cancers, of mobile phones is of obvious public health importance given the wide extent of the exposure. Second, the paper raises several noteworthy methodological issues of general import.

The study of meningiomas in five countries reported in the paper adds two countries to previous articles covering three countries2–4 and is an integral part of a larger multinational study on meningiomas, gliomas, acoustic neurinoma and parotid gland tumours in 13 countries (‘Interphone’)5 whose findings are as yet unpublished. Multi-centric international studies originate and develop within a variety of contexts and constraints, ranging from the degree of urgency of the question under study to the . . . [Full Text of this Article]


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