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IJE Advance Access published online on October 19, 2007
International Journal of Epidemiology, doi:10.1093/ije/dym203
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2007; all rights reserved.

Letter to the Editor

Male circumcision and the risk of HIV infection in men who have sex with men

Sonia L Fankem1,2, Charles Shey Wiysonge1 and Catherine A Hankins1,*

1Joint United Nations Programme on HIV/AIDS (UNAIDS), Geneva, Switzerland.
2University of Arizona Mel and Enid Zuckerman College of Public Health, Tucson, USA.

*Corresponding author. Department of Evidence, Monitoring and Policy, UNAIDS, 20 Avenue Appia, Geneva 27, CH-1211, Switzerland. E-mail: hankinsc@unaids.org SL Fankem and CS Wiysonge contributed equally to this work and share joint first authorship. CA Hankins is guarantor of the article.

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The suggestion by two decades of observational epidemiological data1,2 of a partially protective effect of male circumcision on HIV acquisition in heterosexual men has now been confirmed in three randomized controlled trials conducted in sub-Saharan Africa3–5 Together these trials show that male circumcision reduces the incidence of HIV infection in sexually active, heterosexual men by at least half. However, we are not aware of a published systematic synthesis of the available evidence on the effect of male circumcision . . . [Full Text of this Article]


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