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IJE Advance Access published online on October 5, 2007
International Journal of Epidemiology, doi:10.1093/ije/dym194
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2007; all rights reserved.

Commentary: Aspirin and cancer prevention

Gabriel Kune

Emeritus Professor of Surgery, University of Melbourne, Melbourne, 3010, Australia. E-mail: gkune@unimelb.edu.au

Accepted 24 August 2007

The first 150 words of the full text of this article appear below.

In research the horizon recedes as we advance.

And research is always incomplete

Mark Pattison 1813–84

English Educationist

Isaac Casaubon (1875) Chapter 10

The risk of colorectal cancer in relation to several chronic illnesses, previous operations and medication use was investigated as a part of a large population-based study on colorectal cancer incidence, aetiology and survival, The Melbourne Colorectal Cancer Study, and the results were reported in 1988.1 We had no specific hypotheses regarding any of the medication groups, which were aspirin, non-aspirin, non-steroidal anti-inflammatories, steroids, oral contraceptives, tranquillizers and sleeping pills, and these groups were included as a general category of exposures to be tested in this comprehensive case–control study. There were several findings of interest; however, the focus of this commentary is on the statistically significant protective effect among regular aspirin users for both colon and rectal cancer in both men and women, this being the first . . . [Full Text of this Article]


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