IJE Advance Access first published online on May 17, 2007
This version published online on June 8, 2007
International Journal of Epidemiology, doi:10.1093/ije/dym091
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2007; all rights reserved.
Cohort Profile: The Chennai prospective study of mortality among 500 000 adults in Tamil Nadu, South India
1 Epidemiological Research Center, Chennai, Tamil Nadu, India.
2 International Agency for Research on Cancer, Lyon, France.
3 Clinical Trial Service Unit & Epidemiological Studies Unit, University of Oxford, UK.
* Corresponding author. E-mail: gajaerc@gmail.com
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| How did the study come about? |
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A prospective study of half a million adults living in the city of Chennai (formerly Madras) arose out of discussions at the 1994 International Cancer Congress in Delhi about how to assess the effects of tobacco on health in different parts of India. Chennai is the capital of the South Indian state of Tamil Nadu, and it is India's fourth most populous city. Two large-scale epidemiological studies of tobacco and other factors were established: a case-control study1 that could provide reasonably reliable results quickly, and a prospective cohort study that could provide more robust results over a longer period. (A parallel prospective study of 100 000 adults, not included in this profile, is in progress in the nearby rural area of Villupuram; Figure 1.) The case-control analyses,1 which involved 43 000 adult deaths during 199597 and 35 000 controls who had been living with a case, indicated that smoking
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