IJE Advance Access published online on October 2, 2007
International Journal of Epidemiology, doi:10.1093/ije/dym090
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2007; all rights reserved.
Cohort Profile: The Leicester Respiratory Cohorts
1Swiss Paediatric Respiratory Research Group, Department of Social and Preventive Medicine, University of Berne, Berne, CH-3012, Switzerland.
2The Leicester Children's Asthma Centre, Division of Child Health, Department of Infection, Immunity & Inflammation, University of Leicester, Leicester, LE2 7LX, UK.
3Specialist Community Child Health Services, Leicester City PCT, Bridge Park Plaza, Thurmaston, Leicester, LE4 8PQ, UK
* Corresponding author. E-mail: kuehni@ispm.unibe.ch
Accepted 2 April 2007
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How did the study come about? |
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Asthma and other wheezing disorders are the most common chronic health problems in childhood and place a large burden on children, their families and society.1 Prevalence is highest in infancy or early childhood and the aetiology is complex, with a strong influence of intrauterine and early life exposures. Clinical presentation, response to treatment and prognosis differ by age and the natural history is highly variable. It has been questioned whether asthma, especially in young children, should be regarded as one disease with a single underlying aetiology but a wide range of severity,2 or as a syndrome comprising several separate conditions.3,4 Furthermore, respiratory illness in early life is associated with adult respiratory disease and diminished lung function.5,6 Despite this, most epidemiological studies of asthma before the 1990s had focused on schoolchildren and adults, and there were sparse population-based data on infants and preschool children.
The Leicester respiratory cohort studies were set
How is it funded?
What does it cover?
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Who is in the sample? |
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How often have they been followed-up? What is attrition like? |
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What has been measured? |
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What has been found? Key findings and publications |
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Prevalence, impact and secular trends of respiratory symptoms in preschool children
Risk factors for wheezing disorders
Respiratory disorders in south Asian families
Diagnosis and treatment of wheeze in the community
Natural history and clinical phenotypes of wheeze and chronic cough in childhood
Methodological issues
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What are the main strengths and weaknesses? |
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Can I get hold of the data? Where can I find out more? |
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 B. D. Spycher, M. Silverman, A. M. Brooke, C. E. Minder, and C. E. Kuehni Distinguishing phenotypes of childhood wheeze and cough using latent class analysis Eur. Respir. J., May 1, 2008; 31(5): 974 - 981. [Abstract] [Full Text] [PDF]
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