IJE Advance Access published online on April 10, 2006
International Journal of Epidemiology, doi:10.1093/ije/dyl067
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1 Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, USA; Respiratory and Environmental Health Research Unit, Institut Municipal d'Investigació Mèdica, Barcelona, Spain
* To whom correspondence should be addressed. Objective To examine the relation between prenatal 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p,p'-DDE) exposure (a metabolite of the insecticide DDT) and child growth during the first 7 years of life. Design Prospective cohort study. Participants 1712 children born between 1959 and 1966 with measured p,p'-DDE concentrations in their mother's serum samples from pregnancy. Setting Multicenter US Collaborative Perinatal Project (CPP). Results The highest prenatal concentrations of p,p'-DDE ( Conclusions The findings suggest that high prenatal exposure to p,p'-DDE decreases height in children. Impaired growth may be a general indicator of toxicity and suggests that specific organ systems (e.g. endocrine) could be affected.
Accepted March 14, 2006
Original paper
Prenatal exposure to 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene (p,p'-DDE) in relation to child growth
Núria Ribas-Fitó 1 *,
Beth C. Gladen 2,
John W. Brock 3,
Mark A. Klebanoff 4,
and
Matthew P. Longnecker 2
2 Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, USA
3 Department of Health and Human Services, National Center for Environmental Health, Centers for Disease Control and Prevention, USA
4 Department of Health and Human Services, National Institute of Child Health and Human Development, National Institutes of Health, USA
Núria Ribas-Fitó, E-mail: nribas{at}imim.es
Abstract 
60 µg/l), as compared with the lowest (<15 µg/l), were associated with decreased height at age 1 year [adjusted coefficient (SE) = -0.72 cm (0.37), n = 1540], 4 years [-1.14 cm (0.56), n = 1289], and 7 years [-2.19 (0.46), n = 1371]. Among subjects in lower categories of exposure no association was observed.
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