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IJE Advance Access published online on March 22, 2006
International Journal of Epidemiology, doi:10.1093/ije/dyl049
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2006; all rights reserved.
Accepted March 2, 2006

Original paper

Plasma fibrinogen and lung function: the CARDIA Study

Bharat Thyagarajan 1, David R. Jacobs 2 *, George G. Apostol 1, Lewis J. Smith 3, Cora E. Lewis 4, and O Dale Williams 4

1 Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN, USA
2 Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN, USA; Department of Nutrition, University of Oslo, Oslo, Norway
3 Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
4 Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

* To whom correspondence should be addressed.
David R. Jacobs, E-mail: Jacobs{at}epi.umn.edu


  Abstract

Background We hypothesized that fibrinogen, as a marker of chronic inflammation, is inversely associated with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) in healthy persons.

Methods The CARDIA cohort started in 1985 and included black and white men and women, aged 18-30, from the general population. Spirometry testing conducted at years 5 and 10 [FVC, FEV1, and their ratio (FEV1/FVC)] was studied relative to plasma fibrinogen levels measured at year 5 (cross-sectional n = 4040) and at year 7 (longitudinal n = 3001), controlling for race, sex, age, height, smoking, asthma, body mass index, physical activity, birth control pill use, and alcohol intake.

Results In cross-sectional analyses, FVC at year 5 was lower by 166 ml (95% confidence interval 116-216 ml) in the highest vs lowest year 5 fibrinogen quartile. At year 10, holding year 5 FVC and change in fibrinogen (year 7-year 5) constant, the difference in FVC between the highest and the lowest year 5 fibrinogen quartiles widened by 67 ml (95% CI 31-103 ml). The corresponding differences for FEV1 were 166 ml (95% CI 146-253 ml) at year 5 and 45 ml (95% CI 11-80 ml) widening by year 10. The FEV1/FVC ratio was unrelated to plasma fibrinogen.

Conclusion These findings are consistent with the hypothesis that fibrinogen, possibly as a marker for chronic low-grade inflammation, is associated with modest deterioration of lung function in healthy young adults.

Keywords: Fibrinogen; FEV1; FVC; FEV1/FVC ratio; lung function; inflammation; smoking; asthma; BMI.
A Commentary has been commissioned to accompany this article and will appear with this paper in the printed issue.
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