IJE Advance Access published online on March 11, 2004
International Journal of Epidemiology, doi:10.1093/ije/dyh102
© 2004 by International Epidemiological Association
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1 Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA; Department of Epidemiology, University of Washington, Seattle, Washington, 98195, USA
* To whom correspondence should be addressed. E-mail: nulrich{at}fhcrc.org.
Background Transforming growth factor- Methods We investigated whether this polymorphism was associated with the risk of colorectal adenomatous or hyperplastic polyps in a case-control study of individuals from Minnesota. Risk of colorectal polyps was evaluated separately for individuals with adenomatous polyps (n = 513) and hyperplastic polyps (n = 191) relative to polyp-free controls (n = 606) using logistic regression analysis. Results No overall association was seen between the L10P polymorphism and risk of colorectal adenomatous polyps. The age- and sex-adjusted odds ratios (OR) of developing colorectal hyperplastic polyps were 1.0 (95% CI: 0.7, 1.4) and 0.7 (95% CI: 0.4, 1.1) for individuals with the LP and PP genotypes, respectively, compared with individuals with the LL genotype. When stratified by smoking, evidence for a decreased risk of hyperplastic polyps associated with the P allele was seen only among ever smokers (P for trend = 0.05). Conclusions Whereas adenoma risk did not vary by TGF
Original paper
TGF
1 polymorphism (L10P) and risk of colorectal adenomatous and hyperplastic polyps
2 Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA
Abstract 
1 (TGF1) is a multifunctional signalling molecule with a wide array of roles. Animal experiments suggest that TGF1 plays a biphasic role in carcinogenesis by protecting against the early formation of benign epithelial growths, but promoting malignant transformation of those growths that do develop. A polymorphism in the signal peptide sequence of the TGF1 gene (L10P) has been associated with increased levels of plasma TGF1 in individuals with the P allele.1 L10P genotype, these results suggest that the L10P variant allele may have a protective role in the development of colorectal hyperplastic polyps, possibly consistent with its role as an inhibitor of epithelial growths.
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