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© 1980 Oxford University Press

research-article

The Incidence and Causes of Death in a Follow-up Study of Individuals with Haemoglobin AS and AA

ALICE D STARK*, DWIGHT T JANERICH* and SUSAN K JEREB*

* Bureau of Cancer Control, New York State Department of Health Rockefeller Plaza, Tower Bldg, Room -565, Albany, New York 12237, USA

Stark A D (Bureau of Cancer Control, New York State Department of Health, Rockefeller Plaza, Tower Bldg, Room -565, Albany, New York 12237, USA), Janerich D T and Jereb S K. The incidence and causes of death in a follow up study of individuals with haemoglobin AS and AA. International Journal of Epidemiology 1980, 9: 325–328.

A cohort of 574 black Adults (mean age 47 years with a range of 28–73 years) with sickle cell trait (haemoglobin AS) which had been age and sex matched with 1148 controls (haemoglobin AA) was monitored for 7 years. We found no evidence of excess mortality or differential causes of mortality between cases and controls. There were no case deaths related to kidney disease, splenic infarcts, or pregnancy. Reports in the literature have been inconsistent with regard to the health effects of sickle call trait. These findings suggest that discrimination against trait carriers in terms of life insurance premiums and some job opportunities are unjustified.

Received 22 April 1980


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