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© 1980 Oxford University Press

review-article

Nitrata and Human Cancer: A Review of the Evidence

PATRICIA FRASER1, CLAIR CHILVERS2,*, VALERIE BERAL3 and MICHAEL J HILL4

1, 2 ,3 Epidemiology Monitoring Unit, London School of Hygeene and Topical Medicine Keppel Street (Gower Street), London WC1E 7HT, England
4 Bacterial Metabolism Research Laboratory, Central Public Health Laboratory Colindale, England

* Present address: Division of Epidemiology, Institute of Cancer Research

Fraser P (Epidemiological Monitoring Unit, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street) London WC1, England), Chilvers C, Beral V and Hill M J. Nitrate and human cancer: a review of the evidence. International Journal of Epidemiology 1980, 9: 3–11.

Nitrites, derived mainly from ingested nitrates, may react in vivo with secondary nitrogen compounds occurring naturally in certain foods to form N-nitroso compounds, which are potent carcinogens in laboratory animals. This paper reviews the mechanism of their formation and the evidence from epidemiological studies that high nitrate ingestion is involved in the aetiology of human cancer.

Received 24 October 1979


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