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© 1978 Oxford University Press

research-article

Glucose Tolerance and Blood Pressure in Two Population Samples: Their Relation to Diabetes Mellitus and Hypertension

R J JARRETT1, H KEEN2, M MCCARTNEY3, J H FULLER4, P J S HAMILTON5, D D REID6 and G ROSE7

1Senior lecturer in EpidemiologyUnit for Metabolic Medicine and Department of Community Medicine, Guy's Hospital London Bridge, London SE1 9RT, England
2Professor of Human MetabolismUnit for Metabolic Medicine, Guy's Hospital London, England
3Research StatisticianUnit for Metabolic Medicine and Department of Community Medicine, Guy's Hospital London, England.
4Senior Research Fellow in EpidemiologyUnit for Metabolic Medicine, Guy's Hospital, and Dep. Medical Statistics and Epidemiology, London School of Hygiene and Tropical Medicine London, England.
5DirectorCaribbean Epidemiology Centre, Pan American Health Organisation P.O. Box 164, Port of Spain, Trinidad.
6Professor of EpidemiologyDepartment of Medical Statistics and Epidemiology, London School of Hygiene and Tropical Medicine. (Deceased).
7Professor of EpidemiologyDepartment of Medical Statistics and Epidemiology, London School of Hygiene and Tropical Medicine Keppel Street, Gower Street, London WC1E 7HT, England.

The relationship between blood pressure and the blood sugar concentration measured two hours after a 50 g oral glucose load has been examined in two population surveys — the Whitehall and Bedford Surveys. In the Whitehall Survey, which was conducted in men above the age of 40, there was a positive, significant correlation between blood sugar and blood pressure (systolic and diastolic) which was independent of common associations with age, body mass index (BMI) and heart rate. In the Bedford Survey, systolic blood pressures were significantly higher in newly detected diabetics and borderline diabetics, both men and women, than in normoglycaemic controls after adjustment of blood pressures for age and BMI. However, in the stratified random sample of the cooperating Bedford population, only amongst women was the blood sugar significantly and independently correlated with the systolic blood pressure. Evidence is presented and discussed that autonomic, neurohumoral factors may play some part in the pathogenesis of maturity onset diabetes.

Received 8 July 1977


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