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© 1976 Oxford University Press

research-article

Familial Aggregation of Chronic Respiratory Disease: Use of National Health Interview Survey Data for Specific Hypothesis Testing*

F. E. SPEIZER1,, B. ROSNER2 and I. TAGER3

1Assistant Professor in Medicine, Harvard Medical School, and Chief of the Division of Clinical Epidemiology, Channing Laboratory at Boston City Hospital Boston, Mass. 02118, USA.
2Assistant Professor of Preventive Medicine, Harvard Medical School, and Assistant Professor of Biostatistics, Harvard School of Public Health
3Instructor in Medicine, Harvard Medical School

Reprint requests should be addressed to Dr. F.E. Speizer.

Speizer, F. E. (Division of Clinical Epidemiology, Harvard University, Boston City Hospital, Boston, Mass. 02118, USA), Rosner, B. and Tager, I. Familial aggregation of chronic respiratory disease: use of National Health Interview Survey data for specific hypothesis testing. International Journal of Epidemiology 1976, 5:167-172. The 1970 National Health Interview Survey included questions on respiratory disease and smoking habits. The raw data were released in July 1974. Data consisted of information on approximately 116,000 persons from 37,000 households selected randomly from 357 primary sampling units.

To test a hypothesis about familial clustering of chronic respiratory disease in households, we selected as index households those having an adult (aged 35-54 years) reporting a diagnosis of asthma, bronchitis, or emphysema and also having first order relatives less than age 35. Index households were matched with households from the same neighbourhood having an adult aged 35–54, of the same sex as the diseased person in the index household, without disease and with all other adults 35–54 without disease, and which had first order relatives less than 35 living in the same household.

Analysis was carried out using Cochran's d-test to compare frequency of respiratory disease in persons less than 35 in each group. There was a strong association (P < -001) between persons over 35 with chronic respiratory diseases and the disease rate in their first order relatives. The association could not be explained by differences in demographic variables and smoking habits.

Received 15 December 1975


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