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IJE Advance Access originally published online on November 3, 2008
International Journal of Epidemiology 2009 38(1):274-275; doi:10.1093/ije/dyn232
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2008; all rights reserved.

Commentary: How small is small?

Nicholas Day

Strangeways Research Laboratory, University of Cambridge, Wort's Causeway, Cambridge CB1 8RN, UK.

E-mail: nick.day@cwgsy.net

Accepted 1 October 2008

The first 10% of the full text of this article appears below.

The paper by Prof. Burton and his colleagues1 provides a more comprehensive approach to power calculations than that usually used in population genomics. By incorporating explicitly factors which are known to diminish power, they provide a tool for generating realistic power profiles. This is clearly a useful advance on previous approaches which considered such factors as disease misclassification and measurement error more as nuisance parameters, worthy at best of a footnote. The paper, however, seems to suffer from a certain lack of focus, as if the authors were dazzled by . . . [Full Text of this Article]


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