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IJE Advance Access originally published online on October 24, 2008
International Journal of Epidemiology 2009 38(1):127-128; doi:10.1093/ije/dyn212
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2008; all rights reserved.

Commentary: Can improving a mother's diet improve her children's cardiovascular health?

Caroline Fall

MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton SO16 6YD, UK.

E-mail: chdf@mrc.soton.ac.uk

Accepted 3 September 2008

The first 10% of the full text of this article appears below.

Nearly 20 years ago David Barker and colleagues1 showed a surprising association between low birthweight and an increased risk of adult hypertension, type 2 diabetes and death from cardiovascular disease. They put forward the controversial hypothesis that exposure to undernutrition in fetal life or infancy increases an individual's vulnerability to these disorders. Undernutrition, it was suggested, forced the rapidly growing fetus/infant to make physiological adaptations that enabled short-term survival but ‘programmed’ permanent structural and metabolic changes that caused later disease.1,2 Implicit in the hypothesis is that since the mother's nutritional status influences the quality and quantity of nutrients reaching the . . . [Full Text of this Article]


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