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International Journal of Epidemiology 2008 37(2):231-233; doi:10.1093/ije/dym282
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2008; all rights reserved.

Biorepositories—at the bleeding edge

Teri A Manolio

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-2152, USA.

E-mail: manoliot@nhgri.nih.gov

Accepted 10 December 2007

The first 10% of the full text of this article appears below.

Biorepositories or ‘biobanks,’ that collect and store specimens linked to individual information on health characteristics from large numbers of persons, are increasingly being established for medical research.1–6 Extensive international experience with biorepositories has demonstrated their power and efficiency, but few have fully anticipated the challenges involved in collecting, processing, storing and retrieving very large numbers of samples.

This issue of the International Journal of Epidemiology describes the experience of UK Biobank in planning and implementing a protocol for the collection and archiving of 15 million sample aliquots in 500 000 participants over 4 years, requiring the processing of 19 000 sample aliquots per day. The associated biorepository was designed to house the samples securely and provide them for research use for 20 years or more. Due to its size and complexity, the repository was . . . [Full Text of this Article]


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