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IJE Advance Access originally published online on January 9, 2008
International Journal of Epidemiology 2008 37(1):182-184; doi:10.1093/ije/dym263
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2008; all rights reserved.

Commentary: Ruminant trans fatty acids and coronary heart disease—cause for concern?

Dariush Mozaffarian

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, and Department of Epidemiology and Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.

E-mail: dmozaffa@hsph.harvard.edu

Accepted 6 December 2007

The first 10% of the full text of this article appears below.

In the beginning of the 20th century, the most common source in the modern food supply of trans fatty acids (TFA)—unsaturated fatty acids with at least one unsaturated double bond in the trans configuration—became industrial production of partially hydrogenated oils used for food manufacturing, baking and frying. Strongly concordant evidence from controlled dietary trials evaluating risk factors and observational studies evaluating clinical outcomes indicates that consumption of such industrial TFA significantly increases the risk of coronary heart disease.1

However, a ‘natural’ source of TFA preceded industrial hydrogenation. Bacteria present in stomachs of ruminants (e.g. cattle, sheep, goats) biohydrogenate a proportion of the unsaturated fatty acids consumed by these animals, . . . [Full Text of this Article]


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