Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis
1Department of Public Health, Oxfordshire Primary Care Trust, Richard Building, Old Road Campus, Headington, Oxford OX3 7LG, UK.
2Public Health Resource Unit (PHRU), 4150 Chancellor Court, Oxford Business Park South, Oxford, OX4 2GX, UK.
Corresponding author. Department of Public Health, Oxfordshire Primary Care Trust, Richard Building, Old Road Campus, Headington, Oxford OX3 7LG, UK. E-mail: kcnnoaham{at}yahoo.com
 |
Abstract |
|---|
Objective: To explore the association between low serum vitamin D and risk of active tuberculosis in humans.
Design: Systematic review and meta-analysis.
Data sources: Observational studies published between 1980 and July 2006 (identified through Medline) that examined the association between low serum vitamin D and risk of active tuberculosis.
Results: For the review, seven papers were eligible from 151 identified in the search. The pooled effect size in random effects meta-analysis was 0.68 with 95% CI 0.43–0.93. This ‘medium to large’ effect represents a probability of 70% that a healthy individual would have higher serum vitamin D level than an individual with tuberculosis if both were chosen at random from a population. There was little heterogeneity between the studies.
Conclusions: Low serum vitamin D levels are associated with higher risk of active tuberculosis. Although more prospectively designed studies are needed to firmly establish the direction of this association, it is more likely that low body vitamin D levels increase the risk of active tuberculosis. In view of this, the potential role of vitamin D supplementation in people with tuberculosis and hypovitaminosis D-associated conditions like chronic kidney disease should be evaluated.
Keywords Vitamin D, tuberculosis, systematic review, meta-analysis, vitamin D deficiency
Accepted 13 November 2007
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Roth Evolutionary Speculation About Tuberculosis and the Metabolic and Inflammatory Processes of Obesity JAMA, June 24, 2009; 301(24): 2586 - 2588. [Full Text] [PDF]
|
|
|
|
 |
|
 D. V. Barreto, F. C. Barreto, S. Liabeuf, M. Temmar, F. Boitte, G. Choukroun, A. Fournier, and Z. A. Massy Vitamin D Affects Survival Independently of Vascular Calcification in Chronic Kidney Disease Clin. J. Am. Soc. Nephrol., June 1, 2009; 4(6): 1128 - 1135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. B. Gibney, S. Mihrshahi, J. Torresi, C. Marshall, K. Leder, and B.-A. Biggs The Profile of Health Problems in African Immigrants Attending an Infectious Disease Unit in Melbourne, Australia Am J Trop Med Hyg, May 1, 2009; 80(5): 805 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Wejse, V. F. Gomes, P. Rabna, P. Gustafson, P. Aaby, I. M. Lisse, P. L. Andersen, H. Glerup, and M. Sodemann Vitamin D as Supplementary Treatment for Tuberculosis: A Double-blind, Randomized, Placebo-controlled Trial Am. J. Respir. Crit. Care Med., May 1, 2009; 179(9): 843 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Janssens, A. Lehouck, C. Carremans, R. Bouillon, C. Mathieu, and M. Decramer Vitamin D Beyond Bones in Chronic Obstructive Pulmonary Disease: Time to Act Am. J. Respir. Crit. Care Med., April 15, 2009; 179(8): 630 - 636. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Friis, N. Range, M. L. Pedersen, C. Molgaard, J. Changalucha, H. Krarup, P. Magnussen, C. Soborg, and A. B. Andersen Hypovitaminosis D Is Common among Pulmonary Tuberculosis Patients in Tanzania but Is Not Explained by the Acute Phase Response J. Nutr., December 1, 2008; 138(12): 2474 - 2480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Davey Smith Big business, big science? Int. J. Epidemiol., February 1, 2008; 37(1): 1 - 3. [Full Text] [PDF]
|
|