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International Journal of Epidemiology 2007 36(3):687-689; doi:10.1093/ije/dym118
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2007; all rights reserved.

Commentary: State of the ART modelling for HIV-infected children?

Margaret May1,* and Matthias Egger2

1Department of Social Medicine, University of Bristol, UK.
2Institute for Social and Preventive Medicine, University of Berne, Switzerland.

* Corresponding author. Department of Social Medicine, University of Bristol, UK. E-mail: m.t.may@bristol.ac.uk

Accepted 1 May 2007

The first 10% of the full text of this article appears below.

In sub-Saharan Africa, where the principle transmission route of the human immunodeficiency virus (HIV) is heterosexual sex, it is women and children who bear the greatest burden of HIV infection. The rate of transmission per sex act from an infected man to uninfected women is ~3 times that from an infected woman to an uninfected man, resulting in an HIV prevalence ratio of 60% women to 40% men in many communities.1 Children of HIV-infected mothers are exposed in the womb, during labour and delivery and post-natally through breastfeeding. If they become infected, disease progression is more rapid than in adults,2 but potent anti-retroviral therapy (ART) also greatly reduces mortality in children living in . . . [Full Text of this Article]


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