Skip Navigation


IJE Advance Access originally published online on April 17, 2007
International Journal of Epidemiology 2007 36(3):679-687; doi:10.1093/ije/dym019
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrowOA All Versions of this Article:
36/3/679    most recent
dym019v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Google Scholar
Right arrow Articles by Little, K.
Right arrow Articles by McDermott, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Little, K.
Right arrow Articles by McDermott, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2007; all rights reserved.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Estimating the number of vertically HIV-infected children eligible for antiretroviral treatment in resource-limited settings

Kirsty Little1, Marie-Louise Newell1,*, Chewe Luo2, Ngashi Ngongo2, Mario Cortina Borja1 and Peter McDermott3

1Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health UCL, London, UK.
2Health Section, UNICEF, New York, NY, USA.
3HIV Section, UNICEF, New York, NY, USA.

* Corresponding author. Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health UCL, 30 Guilford Street, London WC1N 1EH, UK. E-mail: m.newell{at}ich.ucl.ac.uk


  Abstract

Background With the gradual roll-out of antiretroviral therapy (ART) to delay progression of HIV disease in children in programmes across sub-Saharan Africa and resource-limited settings elsewhere, reliable information on the number of vertically infected children eligible for such treatment is urgently required.

Methods We present a model to estimate the number of vertically HIV-infected children by age who have progressed to moderate to severe disease (MSD) and as such are eligible for ART on the basis of clinical disease, allowing for: antenatal HIV prevalence, use of interventions to prevent mother-to-child transmission (PMTCT), infant feeding policies and availability of co-trimoxazole to prevent opportunistic infections that may hasten the onset of serious disease. The model assumptions were informed by published evidence and expert opinion; rates of progression to serious disease were inferred from mortality of infected and uninfected children of HIV-infected mothers; and mortality among children treated with ART was based on a study of treated children in Abidjan. To allow widespread use the model has been developed using the Excel spreadsheet software.

Results With South Africa as a hypothetical example, published antenatal prevalence and demographic data, and assuming PMTCT coverage with single dose nevirapine of 11%, all exposed and infected children receive co-trimoxazole, and various infant feeding policy scenarios, estimated numbers of children eligible for ART are presented.

Conclusions This model is easy to implement and flexible and can be used in ART programmes at national and local level.

Keywords HIV, paediatric, vertical transmission, antiretroviral, estimations

Accepted 29 January 2007


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 PediatricsHome page
S. Pahwa, J. S. Read, W. Yin, Y. Matthews, W. Shearer, C. Diaz, K. Rich, H. Mendez, B. Thompson, and for the Women and Infants Transmission Study
CD4+/CD8+ T Cell Ratio for Diagnosis of HIV-1 Infection in Infants: Women and Infants Transmission Study
Pediatrics, August 1, 2008; 122(2): 331 - 339.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.