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IJE Advance Access originally published online on January 24, 2007
International Journal of Epidemiology 2007 36(2):431-438; doi:10.1093/ije/dyl295
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2007; all rights reserved.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Dietary fibre and risk of breast cancer in the UK Women's Cohort Study

Janet Elizabeth Cade*, Victoria Jane Burley, Darren Charles Greenwood the UK Women's Cohort Study Steering Group

Centre for Epidemiology and Biostatistics, University of Leeds, 30-32 Hyde Terrace, Leeds LS2 9PL, UK.

* Correspondence author. E-mail: j.e.cade{at}leeds.ac.uk


  Abstract

Background Reports of relationships between dietary fibre intake and breast cancer have been inconsistent. Previous cohort studies have been limited by a narrow range of intakes.

Methods Women who developed invasive breast cancer, 350 post-menopausally and 257 pre-menopausally, during 240 959 person-years of follow-up in the UK Women's Cohort Study (UKWCS) were studied. This cohort has 35 792 subjects with a wide range of exposure to dietary fibre with intakes of total fibre in the lowest quintile of <20 g/day up to >30 g/day in the top quintile. Fibre and breast cancer relationships were explored using Cox regression modelling adjusted for measurement error. Effects of fibre, adjusting for confounders were examined for pre- and post-menopausal women separately.

Results In pre-menopausal, but not post-menopausal women a statistically significant inverse relationship was found between total fibre intake and risk of breast cancer (P for trend = 0.01). The top quintile of fibre intake was associated with a hazard ratio of 0.48 [95% confidence interval (CI) 0.24–0.96] compared with the lowest quintile. Pre-menopausally, fibre from cereals was inversely associated with risk of breast cancer (P for trend = 0.05) and fibre from fruit had a borderline inverse relationship (P for trend = 0.09). A further model including dietary folate strengthened the significance of the inverse relationship between total fibre and pre-menopausal breast cancer.

Conclusions These findings suggest that in pre-menopausal women, total fibre is protective against breast cancer; in particular, fibre from cereals and possibly fruit.

Keywords Breast neoplasms, cereals, cohort studies, dietary fibre, prospective studies, women


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Home page
 AMERICAN JOURNAL OF LIFESTYLE MEDICINEHome page
D. A. Timm and J. L. Slavin
Dietary Fiber and the Relationship to Chronic Diseases
American Journal of Lifestyle Medicine, June 1, 2008; 2(3): 233 - 240.
[Abstract] [PDF]


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