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IJE Advance Access originally published online on September 15, 2006
International Journal of Epidemiology 2006 35(5):1140-1145; doi:10.1093/ije/dyl199
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2006; all rights reserved.

Cohort Profile

Cohort Profile: The Medical Research Council Cognitive Function and Ageing Study (CFAS){dagger}

Carol Brayne1,*, Cherie McCracken2 and Fiona E Matthews3

1 Department of Public Health and Primary Care, Institute of Public Health, Cambridge University, Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
2 Department of Psychiatry, University of Liverpool University, Clinical Dept Duncan Building Liverpool L69 3BX, UK
3 MRC Biostatistics Unit, Institute of Public Health, Forvie Site, Robinson Way, Cambridge CB2 2SR, UK

* Corresponding author. E-mail: Carol.Brayne@medschl.cam.ac.uk

The first 150 words of the full text of this article appear below.


   Origin of the study
 
Global ageing is a recent phenomenon. Its potential impact on social and economic aspects of more affluent countries highlighted ageing as a sufficiently important issue towards which to direct resources. Discussion between the Department of Health, Medical Research Council, and experts from the scientific and medical communities resulted in the decision that brain changes, most particularly cognitive decline, dementia, and their relation to disability were key topics requiring investigation at the population level. This prompted a decision to invest in research into this area and a working group was convened, which included those with epidemiological and biostatistical expertise relevant to such investigation. Out of this working group a successful bid for the study now known as the MRC Cognitive Function and Ageing Study emerged.


   Study design
 
The study is a six-centre multidisciplinary multiphased longitudinal design (see map, Figure 1). There are five identical sites and one with a different sampling and . . . [Full Text of this Article]


   The aims of the study
 

   What does it cover?
 

   Who is in the sample?
 

   Who is not in the sample?
 

   How, when, and which interviews were conducted?
 

   What is collected at different interviews?
 

   What has the study found?
 

   What are the main strengths?
 

   What are the main weaknesses?
 

   Can I get hold of data?
 

   Where can I find out more?
 

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