IJE Advance Access originally published online on July 26, 2006
International Journal of Epidemiology 2006 35(4):877-879; doi:10.1093/ije/dyl150
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2006; all rights reserved.
Commentary |
Commentary: Early life determinants of blood pressure in childhoodwhere do we go from here?
Division of Community Health Sciences, St George's, University of London, Cranmer Terrace, London. SW17 0RE, UK.
E-mail: pwhincup@sgul.ac.uk
| The first 10% of the full text of this article appears below. |
An important component of the evidence suggesting that cardiovascular disease has its origins in early life, possibly influenced by poor fetal nutrition, is provided by the studies (now more than a hundred in all) that have reported on the relationship between size at birth and subsequent blood pressure. Most of these studies have suggested that small size at birth, particularly lower levels of birth weight, is related to a higher blood pressure in later life, particularly systolic blood pressure.1,2 Despite the large number of studies supporting the existence of this association, much remains uncertain. The strength of the association and its public health importance has been disputed.1 Moreover, the underlying basis of