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IJE Advance Access originally published online on July 17, 2006
International Journal of Epidemiology 2006 35(4):868-870; doi:10.1093/ije/dyl140
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© The Author 2006; all rights reserved.

Commentary

Commentary: Prenatal exposure to diethylstilbestrol (DES): a continuing story

John A McLachlan

Department of Pharmacology and Environmental Endocrinology Lab, Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70112, USA. E-mail: john.mclachlan@tulane.edu

The first 10% of the full text of this article appears below.

When Arthur L Herbst and his colleagues first reported, in 1971,1 an association between the administration of diethylstilbestrol (DES) to pregnant women and cervico-vaginal adenocarcinoma found in their daughters, it was called a ‘biological time bomb’. This was the first documented example of transplacental carcinogenesis in humans—the carcinogen (DES) was taken by the mother, but the cancer appeared in the offspring, and then, only after the onset of puberty.

In addition to these rare genital tract cancers, other alterations were subsequently observed in much higher prevalence in the daughters of DES-exposed mothers—in both humans and . . . [Full Text of this Article]


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