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IJE Advance Access originally published online on April 26, 2006
International Journal of Epidemiology 2006 35(4):1008-1010; doi:10.1093/ije/dyl082
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2006; all rights reserved.

Commentary

Commentary: Fuelling the fire—systemic inflammation and development of lung disease in the general community

Don D Sin1,2,* and SF Paul Man1,2

1 The James Hogg Icapture Center For Cardiovascular, Pulmonary Research, St Paul's Hospital, Vancouver, BC, Canada
2 Division of Respirology, The Department of Medicine, The University of British Columbia, Vancouver, BC, Canada

* Corresponding author. James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul's Hospital, Room #368A, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6. E-mail: dsin@mrl.ubc.ca

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Airway inflammation is associated with reduced lung function.1 With progressive loss in lung function, the inflammatory process intensifies.1 Individuals with increased airway inflammation have a faster decline in lung function, leading to the development of chronic airway diseases such as chronic obstructive pulmonary disease (COPD).2 Once COPD is firmly established, the airways become more vulnerable to additional damage, leading to a further deterioration in lung function, which in turn becomes a substrate for more inflammation.3 The only known therapy that can mitigate this process is smoking cessation.4

Although it has been recognized for more than 30 years that airway inflammation plays a central role in COPD progression . . . [Full Text of this Article]


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