IJE Advance Access originally published online on March 31, 2006
International Journal of Epidemiology 2006 35(3):738-739; doi:10.1093/ije/dyl039
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2006; all rights reserved.
Commentary |
Commentary: Hormones, heart disease, and the definition of hormone initiation
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. E-mail: stampfer@hsph.harvard.edu
| The first 10% of the full text of this article appears below. |
Observational studies consistently find that users of post-menopausal hormone therapy (HT) are at substantially lower risk of coronary heart disease (CHD).1 These results were replicated most recently by Kim et al.,2 in this issue, who find a 24% reduction in risk of myocardial infarction among current HT users. In stark contrast, randomized trials of HT show no overall reduction in CHD and provide convincing evidence for a short-term increase in risk when initiated among women with CHD and possibly among women with no clinical CHD.3 The apparent discrepancy has drawn appropriate scrutiny, and a variety of
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J. Kim, S. Evans, L. Smeeth, and S. Pocock Response: Response to the Stampfer commentary Int. J. Epidemiol., June 1, 2006; 35(3): 740 - 740. [Full Text] [PDF] |
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