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IJE Advance Access originally published online on December 20, 2005
International Journal of Epidemiology 2006 35(2):352-353; doi:10.1093/ije/dyi293
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2005; all rights reserved.

Commentary

Commentary: Benefits of influenza vaccine in US elderly—new studies raise questions

W Paul Glezen1,* and Lone Simonsen2

1 Department of Molecular Virology and Microbiology, and Pediatrics, Baylor College of Medicine, Houston, TX, USA
2 Office of Global Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

* Corresponding author. MVM Department, Baylor College of Medicine, One Baylor Plaza, MS:BCM-280, Houston, TX 77030, USA. E-mail: wglezen@bcm.edu

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During the period from 1989 to 1997 the vaccination rate for elderly persons ≥65 years of age in the US increased from 30 to 67%. Despite this increase in coverage, mortality and hospitalization rates continued to increase rather than decline as would be expected if the vaccine were optimally efficacious. Currently over 50 000 deaths result from influenza virus infections each year in the US.1 The rate of hospitalizations owing to complications of influenza has increased steadily since 1979 and the average number for the last decade is almost 400 000 per year.2 About 85% of deaths and 63% of hospitalizations attributable to influenza occur in persons ≥65 years of age. About two-thirds of the US elderly have been vaccinated each . . . [Full Text of this Article]


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