IJE Advance Access originally published online on November 22, 2005
International Journal of Epidemiology 2006 35(2):288-293; doi:10.1093/ije/dyi247
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Article |
Maternal cigarette smoking and the risk of pregnancy-induced hypertension and eclampsia
1 OMNI Research Group, Department of Obstetrics and Gynecology, University of Ottawa, Faculty of Medicine, Ontario, Canada
2 Ottawa Health Research Institute, Clinical Epidemiology Program, Ontario, Canada
3 McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, Ontario, Canada
4 Department of Epidemiology and Community Medicine, University of Ottawa, Ontario, Canada
5 Queen's Perinatal Research Unit, Queen's University, Ontario, Canada
* Corresponding author. OMNI Research Group, Department of Obstetrics and Gynecology, The Ottawa Hospital, General Campus, 501 Smyth Road, Box 241, Ottawa, Ontario, Canada K1H 8L6. E-mail: qyang{at}ohri.ca
Background Although previous studies have found that maternal smoking decreases the risk of pregnancy-induced hypertension (PIH), the difference of this effect between primiparous and multiparous women has not been well studied and the results of the exposure–response relationships between maternal smoking and PIH are inconsistent. No previous study has specifically examined the relationship between maternal smoking and eclampsia.
Methods We analysed data from a population-based retrospective cohort study of 3 153 944 singleton pregnancies in the US. The data were derived from the national linked birth/infant mortality database for 1998. Multiple logistic regressions were used to describe the relationship between cigarette smoking and PIH and eclampsia.
Results The adjusted odds ratios (ORs) [95% confidence intervals (95% CIs)] for PIH were 0.80 (0.77–0.83) for primiparous women and 0.81 (0.78–0.83) for multiparous women among smokers compared with non-smokers. The corresponding adjusted ORs (95% CIs) for eclampsia were 0.74 (0.66–0.82) and 0.75 (0.68–0.83), respectively. For PIH, the adjusted OR (95% CI) for smokers vs non-smokers were 0.82 (0.79–0.86), 0.81 (0.78–0.83), 0.80 (0.77–0.83), and 0.88 (0.79–0.98), respectively, for 1–5, 6–10, 11–20, and >20 cigarettes per day (test for trend: P = 0.86). The corresponding figures for eclampsia were 0.85 (0.75–0.95), 0.74 (0.66–0.82), 0.68 (0.58–0.78), and 0.73 (0.49–1.04), respectively (test for trend: P = 0.02).
Conclusion Maternal cigarette smoking decreases the risk of PIH and eclampsia, with a significant inverse exposure–response relationship apparent for eclampsia.
Keywords Smoking, pregnancy-induced hypertension, eclampsia, dose–response, parity
Accepted 13 October 2005
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  F. B. Pipkin and on behalf of The Genetics of Preeclampsia Consorti Smoking in Moderate/Severe Preeclampsia Worsens Pregnancy Outcome, but Smoking Cessation Limits the Damage Hypertension, April 1, 2008; 51(4): 1042 - 1046. [Abstract] [Full Text] [PDF]
|
|