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IJE Advance Access originally published online on November 22, 2005
International Journal of Epidemiology 2006 35(2):227-230; doi:10.1093/ije/dyi263
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2005; all rights reserved.

Commentary

Commentary: Sunlight, vitamin D, and the cancer connection revisited

Kathleen M Egan

Vanderbilt-Ingram Cancer Center, Health Services Research, Vanderbilt University, 6000 Medical Center East, Nashville, TN 37235, USA. E-mail: kathleen.egan@Vanderbilt.Edu

The first 150 words of the full text of this article appear below.

This discussion commemorates the 25th anniversary of the publication in this journal of the report by Cedric and Frank Garland that first raised the hypothesis that vitamin D—the so-called ‘sunlight vitamin’—might have a protective influence on colon cancer.1 As research in this area has accelerated, most rapidly in only the last few years, the Garlands' insights can now be fully recognized. Experimental, clinical, and epidemiological data is pointing to a beneficial role of vitamin D, not only for colorectal malignancy but also potentially for many of the most common and lethal forms of cancer in temperate climates. Vitamin D is a fat-soluble vitamin that is essential as a positive regulator of calcium homeostasis. The term ‘vitamin D’ is something of a misnomer as all of the human requirement can be obtained from a non-nutritive source: ultraviolet radiation (UVR) in sunlight. In the skin, 7-dehydrocholesterol (pro-vitamin D3) is photolysed by ultraviolet . . . [Full Text of this Article]


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