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IJE Advance Access originally published online on January 4, 2006
International Journal of Epidemiology 2006 35(1):166-168; doi:10.1093/ije/dyi301
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2006; all rights reserved.

Commentary

Commentary: Weight gain, weight loss, and endometrial cancer

Penelope M Webb

Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Qld 4029, Australia. E-mail: Penny.webb@qimr.edu.au

The first 10% of the full text of this article appears below.

It has long been recognized that women who develop endometrial cancer are often overweight1 and obesity is now clearly established as a major risk factor for the disease.2 In pre-menopausal women, obesity is associated with an increased frequency of anovulatory cycles and, as a result, the endometrium is exposed to oestrogen in the absence of progesterone. Among post-menopausal women, obesity is again associated with exposure to higher levels of endogenous oestrogen as a result of increased conversion of androstenedione to oestrone in adipose tissue and lower levels of sex-hormone binding globulin (SHBG). In the absence of progesterone, unopposed oestrogen stimulates cellular proliferation in the endometrium leading to hyperplasia and, potentially, cancer.3

It has been estimated that up to 40% of all endometrial cancers could be related to obesity,2 a figure that is rising as the prevalence of obesity increases.4 More than 1.1 billion adults worldwide are now . . . [Full Text of this Article]


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