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IJE Advance Access originally published online on May 24, 2005
International Journal of Epidemiology 2005 34(4):931-935; doi:10.1093/ije/dyi103
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2005; all rights reserved.

Cancer

Breast cancer incidence, case-fatality and breast cancer mortality in Danish women using hormone replacement therapy—a prospective observational study

Claudia Stahlberg1,*, Elsebeth Lynge2, Zorana Jovanovic Andersen3, Niels Keiding3, Bent Ottesen1, Fritz Rank4,5, Yrsa Andersen Hundrup6, Erik B Obel6 and Anette Tønnes Pedersen1

1 Department of Gynaecology, Juliane Marie Centre, H:S Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
2 Institute of Public Health, University of Copenhagen, Copenhagen, Denmark
3 Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark
4 Department of Pathology, Centre of Diagnostic Investigations, H:S Rigshospitalet, University of Copenhagen, Denmark
5 DBCG-registry, H:S Rigshospitalet Department 7003, Copenhagen, Denmark
6 The Danish Nurse Cohort, The National Institute of Public Health, Copenhagen, Denmark

* Corresponding author: Department of Gynaecology, Juliane Mavie Centre, H:S Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. E-mail: c.stahlberg@dadlnet.dr

Keywords Hormone replacement therapy, breast neoplasm, prognosis, mortality, epidemiology, estrogen, progestin, menopause

Accepted 19 April 2005

The first 150 words of the full text of this article appear below.

It is well-established knowledge from both observational studies and randomized controlled trials that hormone replacement therapy (HRT) increases the risk of breast cancer.1–8 However, several studies have proposed that breast cancers developing in women using HRT may be more favourable with respect to one or more prognostic characteristics, implying that the prognosis may be better for breast cancers developing in women having used HRT before or at the time of diagnosis as compared with those of never users.9–17 A recent review of ten prospective cohort studies on breast cancer mortality showed both increased and reduced risk estimates of breast cancer mortality with HRT.18 A Danish study on breast cancer incidence and mortality according to social class showed increased mortality from breast cancer as well as increased incidence throughout higher social classes.19 More recently the Million Women's Study found a 22% increased risk of breast cancer mortality in users of HRT.2 . . . [Full Text of this Article]


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   Conflicts of interest
 

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