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IJE Advance Access originally published online on April 15, 2005
International Journal of Epidemiology 2005 34(3):711; doi:10.1093/ije/dyi086
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Published by Oxford University Press on behalf of the International Epidemiological Association

Letters to the Editor

Case recruitment in genetic association studies: larger sample size or greater homogeneity?

Chuen-Fei Chen and Wen-Chung Lee

Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, No. 1, Jen-Ai Road, 1st Section, Taipei, Taiwan. E-mail: wenchung@ha.mc.ntu.edu.tw

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Sirs—To study the genetic components of complex human diseases, researchers nowadays are relying heavily on the case–control association designs. However, they are often in a dilemma as to whether they should recruit as many affected cases as they can in a study (even though the affected cases recruited in this way may constitute a heterogeneous group), . . . [Full Text of this Article]


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