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IJE Advance Access originally published online on January 19, 2005
International Journal of Epidemiology 2005 34(2):475-476; doi:10.1093/ije/dyi005
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Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2005; all rights reserved.

Commentary

Commentary: Is tooth loss good or bad for general health?

Yu-Kang Tu1,2 and Mark S Gilthorpe1,*

1 Biostatistics Unit, Centre for Epidemiology and Biostatistics, Leeds Institute for Genetics, Health and Therapeutics, 30/32 Hyde Terrace, Leeds, LS2 9LN, UK.
2 Department of Periodontology, Leeds Dental Institute, Clarendon Way, Leeds, LS2 9LU, University of Leeds, UK.

* Corresponding author: Biostatistics Unit, Centre for Epidemiology and Biostatistics, Leeds Institute for Genetics, Health and Therapeutics, 30/32 Hyde Terrace, Leeds, LS2 9LN, UK. E-mail: m.s.gilthorpe@leeds.ac.uk

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Abnet et al.1 show that tooth loss is associated with increased risk of mortality from upper gastrointestinal cancer, heart diseases, and stroke. In the last decade, those working in oral health research, especially within periodontology, have shown increasing interest in studying the possible link between oral health and systemic health outcomes. The study by Abnet et al. evidently shows the difficulties and limitations in study design faced by proponents of a causal relationship. It is simple to think of a randomized controlled trial to test the hypothesis of a relationship between oral health status and systemic health outcomes (not surrogate endpoints such as inflammatory cytokine levels): . . . [Full Text of this Article]


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