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IJE Advance Access originally published online on January 19, 2005
International Journal of Epidemiology 2005 34(1):149-151; doi:10.1093/ije/dyi011
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IJE vol.34 no.1 © International Epidemiological Association 2005; all rights reserved.

Commentary

Commentary: Contrary findings from Guinea-Bissau and Papua New Guinea

Peter Aaby* and Henrik Jensen

Bandim Health Project, Danish Epidemiology Science Centre/Statens Serum Institut, Apartado 861, Bissau, Guinea-Bissau

* Corresponding author. E-mail: psb@mail.gtelecom.gw

The first 150 words of the full text of this article appear below.

About four years ago, a study of routine immunizations in rural areas of Guinea-Bissau suggested that early BCG and measles vaccination (MV) were associated with reduced mortality, which was not explained by the prevention of TB or measles, but that early diphtheria-tetanus-pertussis (DTP) vaccine was associated with increased mortality.1 Given the observational design and the potential for bias, a precise estimate of these effects could not be established, but it was noteworthy that different vaccines had opposite effects.1–3 Several studies from Bissau, Senegal, and Benin have found similar patterns of BCG and MV being associated with lower mortality and DTP with higher mortality.4–10 These effects are most marked immediately after vaccination and until the next vaccine is received. When DTP has been the last vaccine received, it has been associated with a higher mortality for girls.3–7,9 WHO withdrew high-titre measles vaccine (HTMV) because it was associated with increased female mortality;9 . . . [Full Text of this Article]


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G. J Chan, L. H Moulton, S. Becker, A. Munoz, and R. E Black
Non-specific effects of diphtheria tetanus pertussis vaccination on child mortality in Cebu, The Philippines
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