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IJE Advance Access originally published online on August 19, 2004
International Journal of Epidemiology 2004 33(6):1182-1183; doi:10.1093/ije/dyh288
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IJE vol.33 no.6 © International Epidemiological Association 2004; all rights reserved.

Commentary

Commentary: Fifty years of the multistage model: remarks on a landmark paper

Suresh H Moolgavkar

Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. E-mail: moolgavkar@earthlink.net

The first 10% of the full text of this article appears below.

Fifty years after its publication, the multistage model proposed by Armitage and Doll1 continues to influence biological and epidemiological thinking on the processes underlying carcinogenesis. I am pleased that the International Journal of Epidemiology has chosen to republish Armitage and Doll's landmark paper, and I am honoured to write a commentary on it.

With the rapid advances in molecular biology over the last 50 years, we know a lot more about the process of carcinogenesis than we did when Armitage and Doll wrote their paper. Yet, the fundamental predicate on which their model is based, that malignant transformation of a normal cell results . . . [Full Text of this Article]


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