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International Journal of Epidemiology 2004 33(5):989-994; doi:10.1093/ije/dyh367
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IJE vol.33 no.5 © International Epidemiological Association 2004; all rights reserved.

Commentary

Commentary: Vitamin D receptor polymorphism and bone mineral density: effect size in Caucasians means detection is uncertain in small studies

Nigel Morrison

School of Health Science, Griffith University, Gold Coast, Australia. E-mail: n.morrison@griffith.edu.au

The first 150 words of the full text of this article appear below.

Vitamin D receptor (VDR) is a nuclear hormone receptor that acts as a transcriptional regulator in response to circulating 1,25 dihydroxyvitamin D3, the active hormonal form of vitamin D. VDR gene polymorphism (VDRGP) have been extensively studied in different diseases, with over 700 primary research articles, although this has focused mainly on the same markers. The VDRGP experience, with its huge literature and appearance of apparently contradictory reports each month, may provide an example of what to expect with other genes in the growing field of analysis of common gene polymorphisms with complex common disorders. Morita et al. provide a typical example of a moderately sized population study of the relationship of VDRGP to bone density and rate of bone loss in Japanese.1 Reviewing the VDRGP literature is beyond the scope of this commentary which will only refer to a limited number of publications. For those interested, Zmuda . . . [Full Text of this Article]


   VDR polymorphisms
 

   Multifactorial traits and BMD
 

   The standard quantitative model
 

   What is the effect size of VDRGP?
 

   Haplotypes in different ethnic groups
 

   Conclusions
 

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