IJE Advance Access originally published online on May 27, 2004
International Journal of Epidemiology 2004 33(5):948-953; doi:10.1093/ije/dyh117
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
IJE vol.33 no.5 © International Epidemiological Association 2004; all rights reserved.
Special Theme: Genetic Epidemiology |
Low birthweight and Type 2 diabetes: A study on 11 162 Swedish twins
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Correspondence: Anastasia Iliadou, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, 171 77 Stockholm, Sweden. E-mail: Anastasia.iliadou{at}meb.ki.se
Background To investigate the association between low birthweight and diabetes in a population-based Swedish twin sample.
Method A cohort of 11 162 same-sexed Swedish twins born between 1906 and 1958 was used in order to investigate the risk of developing Type 2 diabetes between and within twin pairs by utilizing random effects linear models.
Results Between pairs there was a significant increase in risk of developing Type 2 diabetes for a 1-kg increase in their mean birthweight (odds ratio [OR] = 2.13; P < 0.01), adjusted for age, sex, body mass index (BMI), and smoking status. The corresponding risk within pair was 2.03 (P = 0.07) for monozygotic twins and 1.15 (P = 0.71) for dizygotic twins. The test of the heterogeneity of the within and between effects showed no significant difference between the estimates.
Conclusions The study suggests that reduced fetal growth increase the risk of Type 2 diabetes due to an in utero programming effect possibly caused by intrauterine malnutrition. However, it does not exclude the possibility of a common genetic mechanism.
Keywords Twins, diabetes mellitus, non-insulin-dependent, birthweight
Accepted 14 January 2004
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  W. Xu, C. Qiu, M. Gatz, N. L. Pedersen, B. Johansson, and L. Fratiglioni Mid- and Late-Life Diabetes in Relation to the Risk of Dementia: A Population-Based Twin Study Diabetes, January 1, 2009; 58(1): 71 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. W. H. Rumball, J. E. Harding, M. H. Oliver, and F. H. Bloomfield Effects of twin pregnancy and periconceptional undernutrition on maternal metabolism, fetal growth and glucose-insulin axis function in ovine pregnancy J. Physiol., March 1, 2008; 586(5): 1399 - 1411. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Bergvall, A. Lindam, Y. Pawitan, P. Lichtenstein, S. Cnattingius, and A. Iliadou Importance of familial factors in associations between offspring birth weight and parental risk of type-2 diabetes Int. J. Epidemiol., February 1, 2008; 37(1): 185 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Stocker, E. Wargent, J. O'Dowd, C. Cornick, J. R. Speakman, J. R. S. Arch, and M. A. Cawthorne Prevention of diet-induced obesity and impaired glucose tolerance in rats following administration of leptin to their mothers Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1810 - R1818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. H. Bloomfield, M. H. Oliver, and J. E. Harding Effects of twinning, birth size, and postnatal growth on glucose tolerance and hypothalamic-pituitary-adrenal function in postpubertal sheep Am J Physiol Endocrinol Metab, January 1, 2007; 292(1): E231 - E237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.-M. Alexe, G. Syridou, and E. Th. Petridou Determinants of Early Life Leptin Levels and Later Life Degenerative Outcomes Clin. Med. Res., December 1, 2006; 4(4): 326 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-Y. Tian, Q. Cheng, X.-M. Song, G. Li, G.-X. Jiang, Y.-Y. Gu, and M. Luo Birth weight and risk of type 2 diabetes, abdominal obesity and hypertension among Chinese adults. Eur. J. Endocrinol., October 1, 2006; 155(4): 601 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H Hemachandra, M. A Klebanoff, A. K Duggan, J. B Hardy, and S. L Furth The association between intrauterine growth restriction in the full-term infant and high blood pressure at age 7 years: results from the Collaborative Perinatal Project Int. J. Epidemiol., August 1, 2006; 35(4): 871 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F H Bloomfield, M H Oliver, and J E Harding The late effects of fetal growth patterns. Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2006; 91(4): F299 - F304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B Carlin, L. C Gurrin, J. A. Sterne, R. Morley, and T. Dwyer Regression models for twin studies: a critical review Int. J. Epidemiol., October 1, 2005; 34(5): 1089 - 1099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T.-M. Hng, N. W. Cheung, and M. McLean Growth Hormone and Cortisol Dynamic Function in Relation to Birth Weight: A Study in Adult Twins J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2781 - 2786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Smith Epidemiological Freudianism Int. J. Epidemiol., February 1, 2005; 34(1): 1 - 2. [Full Text] [PDF]
|
|
|
|
|
|
L. J Palmer The New Epidemiology: putting the pieces together in complex disease aetiology Int. J. Epidemiol., October 1, 2004; 33(5): 925 - 928. [Full Text] [PDF]
|
|
|
|
|
|
D. Phillips Commentary: Twins, low birthweight and type 2 diabetes Int. J. Epidemiol., October 1, 2004; 33(5): 953 - 954. [Full Text] [PDF]
|
|