International Journal of Epidemiology, Volume 33, Number 2, pp. 381
IJE vol.33 no.2 © International Epidemiological Association 2004; all rights reserved.
Commentary |
Commentary: Vaccines and unexpected events
London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK. E-mail: andy.hall{at}lshtm.ac.uk
| The first 10% of the full text of this article appears below. |
Exposure to antigenic stimulation of our immune system begins in utero. It intensifies from the moment of birth with multiple infectious stimuli. These infections occur with a range of intensity and in a vast array of sequence. Thus a child may meet respiratory syncytial virus before or after influenza or their first coronavirus. Not only the sequence but the age at which they meet each infection may be critical to how they respond. This is