International Journal of Epidemiology, Volume 33, Number 2, pp. 243-246
IJE vol.33 no.2 © International Epidemiological Association 2004; all rights reserved.
Article |
Clinical trial of patulin in the common cold
Report of the Patulin Clinical Trials Committee, Medical Research Council
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In November, 1943, a report was published of the chemical properties and clinical effects of a metabolic product of Penicillium patulum Bainier, called patulin.1 It was shown in a clinical trial on the common cold in naval personnel that when 95 patients treated with patulin were compared with 85 controls, the advantage to the treated patients was such that it would usually be regarded as statistically significant. The results obtained were considered encouraging, but no definite claims were made.
The discovery of an effective treatment for the common cold being a matter of such great practical importance, it was clearly desirable that this suggestion be reinvestigated as soon as possible. This was rendered the more necessary because, shortly after the publication of the first report, a second and independent group of workers stated that they had been unable to demonstrate any effect of patulin on the common cold.2 The Medical
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Investigation |
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Selection of cases
Recording
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Treatment |
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