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International Journal of Epidemiology, Volume 33, Number 1, pp. 161-162
IJE vol.33 no.1 © International Epidemiological Association 2004; all rights reserved.

Special Theme: Perinatal and early-life influences on disease

Commentary: Birthweight arterial stiffness and blood pressure: in search of a unifying hypothesis

Ian B Wilkinson1 and John R Cockcroft2

1 Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK
2 Wales Heart Research Unit, University of Wales College of Medicine, University Hospital, Heath Park, Cardiff CF14 4XN, UK

Correspondence: Professor John Cockcroft, Wales Heart Research Unit, University of Wales College of Medicine, University Hospital, Heath Park, CARDIFF CF14 4XN, UK. E-Mail: cockcroftjr@cf.ac.uk

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Arterial stiffness is a major, independent risk factor for the development of cardiovascular disease and also an important predictor of outcome. In addition, increased arterial stiffness may play a role in the development of hypertension.1 Although a body of evidence already exists linking low birthweight to the development of hypertension in later life, this has recently been challenged.2 Nevertheless, a unifying hypothesis linking fetal growth retardation to increased arterial stiffness and the future development of hypertension remains an attractive one.3 To date . . . [Full Text of this Article]


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