International Journal of Epidemiology 2003;32:1103-1104
© International Epidemiological Association 2003
Paediatric Epidemiology |
Commentary: Zinc and child growth
Program in International Nutrition and Department of Nutrition, University of California, Davis, CA 95616, USA. E-mail: khbrown@ucdavis.edu
| The first 10% of the full text of this article appears below. |
Zinc is an essential nutrient, which is required to maintain the normal structure and/or function of multiple enzymes, including those that are involved in transcription and translation of genetic material and ultimately, therefore, in cell division.1 Early research in experimental animals demonstrated the critical importance of zinc for normal dietary intake and physical growth.2 These results suggested that zinc nutriture might also influence the growth of young children, particularly in resource-poor countries where dietary intake or absorption of zinc may be inadequate3 and/or excessive zinc losses may occur due to frequent enteric infections.4 Nevertheless, the lack of simple, objective biomarkers of zinc status has hindered the ability to implicate zinc nutriture unequivocally as a cause of growth failure in humans.
In an attempt to shed more light on this topic, we recently prepared a quantitative review of 33 previously completed studies of the effect
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