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International Journal of Epidemiology 2003;32:876-877
© International Epidemiological Association 2003

Fetal Origins Of Adult Health

Commentary: Developmental origins of raised serum cholesterol

DJP Barker

MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. E-mail: djpb@mrc.soton.ac.uk

The first 10% of the full text of this article appears below.

Human beings are plastic during development, and a single genotype can produce more than one alternative form of structure or physiological state in response to environmental conditions.1 There is now a considerable body of evidence that coronary heart disease (CHD) originates in developmental plasticity.2 That being the case environmental conditions during development should be linked to the major biological risk factors for the disease. In this issue of the International Journal of Epidemiology, Liisa Lauren and colleagues3 review the evidence that low birthweight, a marker of an adverse . . . [Full Text of this Article]


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