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International Journal of Epidemiology 2003;32:577-578
© International Epidemiological Association 2003

Cancer

Commentary: Case-control studies of screening should carry a health warning

AE Raffle

Consultant in Public Health Medicine. Bristol North Primary Care Trust, King Square House, King Square Bristol, BS2 8EE, UK. E-mail angela.raffle@bristolnorth-pct.nhs.uk

The first 10% of the full text of this article appears below.

In 1991 George Knox published an unequivocal condemnation of misuses of case-control methods for evaluating screening.1 Noel Weiss countered some of Knox’s criticisms, arguing that carefully conducted and cautiously interpreted case-control studies may be the only option in circumstances where other evidence is unavailable.2 Whilst Weiss’s arguments are valid, Knox’s criticisms were justifiable given the poor scientific rigour of many publications that had claimed to elucidate the outcomes of screening. Faced with Hoffman et al.’s paper3 it is hard not to have a sense of déjà vu.

Not only are there theoretical concerns. Experience with nationwide quality assured programmes . . . [Full Text of this Article]


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