International Journal of Epidemiology 2003;32:60-63
© International Epidemiological Association 2003
Special Theme: Genetic Epidemiology |
Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years
1 Molecular and Genetic Epidemiology Unit, Ospedale Maggiore IRCCS, Italy;
2 INSERM, Villejuif, France, and Geneva Cancer Registry;
3 IARC, Lyon, France;
4 Institute of Clinical Pharmacology, Georg August University, Goettingen, Germany;
5 Institute of Clinical Pharmacology, Gliwice, Poland;
6 Ernst Moritz Arndt University, Greifswald, Germany;
7 Fox Chase Cancer Center, Philadelphia, PA USA;
8 University of Ljubljana, Slovenia;
9 National Institute of Occupational Health, Oslo, Norway;
10 Finnish Institute of Occupational Health Helsinki, Finland;
11 PJ 
afárik University, Ko
ice, Slovakia;
12 Institut de Pathologie, Liège-Belgium;
13 University of Hawaii-Honolulu, HA, USA;
14 National Institute for Environmental Health Sciences Research Triangle Park, NC USA;
15 Karolinska Institutet Stockholm, Sweden;
16 University of Pittsburgh, Pittsburgh, PA USA;
17 National Institute of Environmental Health, Budapest, Hungary;
18 Lund University, Lund, Sweden;
19 Keele University, Staffordshire UK;
20 INSERM, Villejuif, France;
21 Hospital Clinic Provincial, Barcelona, Spain;
22 EOHSI, UMDNJ, Picataway, NJ USA and Genetics Research Institute Milano, Italy.
Background A genetic component of early-onset lung cancer has been suggested. The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens’ metabolism and therefore in lung cancer risk.
Methods The effect of metabolic gene polymorphisms on lung cancer at young ages was studied by pooling data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database. All primary lung cancer cases of both sexes who were Caucasian and 
45 years of age at diagnosis, and the corresponding controls were selected. We obtained 261 cases and 1452 controls.
Results There was a marginally significant association between lung cancer and GSTT1 null genotype (OR=1.2; 95% CI:1.0–1.6), and a significant association between lung cancer and the homozygous CYP1A1 Msp1 variant allele (CYP1A1*2A and *2B) genotype (OR=4.7 95% CI:1.2–19.0). When data were stratified by smoking status, the association between CYP1A1 genotype and lung cancer was confined to never smokers.
Conclusions These results suggest that metabolic genetic factors play a role in lung cancer developing at young ages.
Accepted 26 April 2002
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