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International Journal of Epidemiology 2003;32:48-50
© International Epidemiological Association 2003

Special Theme: Genetic Epidemiology

Commentary: Case-control-family designs: a paradigm for future epidemiology research?

John L Hopper

The University of Melbourne, Centre for Genetic Epidemiology, 723 Swanston Street, Carlton, Victoria 3053, Australia.

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The Human Genome Project and its associated technologies have opened up many new opportunities for epidemiology, one being the ability to test if the effects of risk factors depend on the individual’s genotype. As an early foray into this area, in this issue of the International Journal of Epidemiology Becher et al.1 report findings on potential differences in the effects of some breast cancer risk factors according to the likely genetic predisposition of the woman at risk, based on her family history. The findings are interesting in generating hypotheses, and are appropriately expressed with an appreciation of limitations in statistical power due to the indirect measures of genetic susceptibility, especially when using sister controls. There are a number of important novel and interesting features in this work, not the least being the use of . . . [Full Text of this Article]


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M. J Khoury, R. Millikan, J. Little, and M. Gwinn
The emergence of epidemiology in the genomics age
Int. J. Epidemiol., October 1, 2004; 33(5): 936 - 944.
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