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International Journal of Epidemiology 2003;32:161-162
© International Epidemiological Association 2003

Letters to the Editor

Is all-cause mortality a useful epidemiological endpoint in vaccine trials? An example of BCG (Bacille-Calmette-Guerine)

Zubair Kabir

Department of Respiratory Medicine, University of Dublin (Trinity College), St James’s Hospital, Dublin 8, Ireland. E-mail: kabirz@tcd.ie

The first 10% of the full text of this article appears below.

Sirs—Since 1978, the WHO/UNICEF Expanded Programme on Immunization has led to steady reductions in childhood mortality from the vaccine preventable diseases both in developed and less-developed nations. Surprisingly, scant attention has been paid to the overall effect of routine vaccines. In general, we have taken vaccines and schedules that are effective in developed nations with low levels of child mortality and used them in high mortality populations without studying their effects on all-cause mortality.

As early as the mid-1970s, measles vaccination showed an overall improvement in the probability of child survival, . . . [Full Text of this Article]


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