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International Journal of Epidemiology 2002;31:1051-1053
© International Epidemiological Association 2002

Cardiovascular Disease

Commentary: Modifying body weight not birthweight is the key to lowering blood pressure

Rachel Huxley

Institute for International Health, 144 Burren Street, Newtown, Sydney, NSW 2042, Australia. E-mail: rhuxley@iih.usyd.edu.au

The first 10% of the full text of this article appears below.

The fetal-origins hypothesis suggests that an adverse early life environment can have a profound and long-lasting impact on an individual’s health in later life.1 A central tenet of the hypothesis is a reported inverse association between birthweight, which is often used as a surrogate measure of fetal nutrition, with subsequently raised blood pressure or hypertension.2 This inverse association between birthweight and blood pressure (but less so with hypertension) has been reported widely in the literature and is considered to provide some of the strongest evidence for an association between an adverse early life environment and chronic disease,3 although a recent overview of the evidence casts doubt on . . . [Full Text of this Article]


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