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International Journal of Epidemiology 2002;31:495-496
© International Epidemiological Association 2002

Cardiovascular Disease

Commentary: Geographical distribution of sporadic Creutzfeldt-Jakob Disease in France

Martin Kulldorff

Division of Biostatistics, Department of Community Medicine, University of Connecticut School of Medicine, Farmington, CT 06030–6325, USA. E-mail: MartinK@neuron.uchc.edu

In this issue of the International Journal of Epidemiology Huillard d'Aignaux et al.1 present a very interesting geographical analysis of sporadic Creutzfeldt-Jakob Disease in France. A number of non-traditional statistical methods are used, and here we offer some comments regarding their purpose and interpretation.

Tests for Spatial Randomness

An important first step in any geographical investigation of disease is to present a descriptive map, such as the one provided by Huillard d'Aignaux et al.1 in Figure 1. Whether or not there are true geographical differences in risk, there will always be some geographical patterns apparent to the naked eye. For example, in the aforementioned map, . . . [Full Text of this Article]

Data Quality and Interpretation

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