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International Journal of Epidemiology 2002;31:123-124
© International Epidemiological Association 2002

Special Theme: Systematic Reviews and Meta-Analysis

Commentary: Searching for trials for systematic reviews: what difference does it make?

Mike Clarke

UK Cochrane Centre, NHS R&D Programme, Summertown Pavilion, Middle Way Oxford OX2 7LG, UK. E-mail: mclarke@cochrane.co.uk

Systematic reviews are increasingly common as a means of assessing the relative effectiveness of health care interventions. This is not least because of the formation of the Cochrane Collaboration with its aim to prepare, maintain and promote the accessibility of reviews in all areas of health care.1 Just as systematic reviews contribute to the practice of evidence-based health care, so should the conduct of reviews be based on good evidence, ideally from empirical research. The paper by Juni et al.2 adds to this evidence base.

For all but the last century, decisions on how to treat patients were almost always based on personal experience, anecdotal case histories and highly selective retrospective . . . [Full Text of this Article]

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