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International Journal of Epidemiology 2001;30:1438-1439
© International Epidemiological Association 2001

Cancer

Commentary: Birth order and risk of childhood acute lymphoblastic leukaemia (ALL)

MF Greaves

LRF Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK. E-mail: m.greaves@icr.ac.uk

In this issue of the International Journal of Epidemiology, Dockerty and colleagues1 report a case-control study in which a number of parental, familial and social factors were evaluated in relation to risk of different childhood cancers. The rationale of the study is a rather curious mix of four different hypotheses, only loosely interconnected by the parameters studied. But it does have two outstanding features—its very large size and a design that minimizes selection bias. These provide the potential for robust statistical inquisition of associations, or the lack thereof. Cases (age 0–14 years) total almost 11 000 including 3878 leukaemias, all accrued from the British National Registry of Childhood Tumours for the . . . [Full Text of this Article]

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